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Contraceptive pills usually change the way your periods work. TriRegol uses three different dosages to match the natural rhythm of your period. Most other pills only use a single dose instead.

TriRegol could be right for you if you’re looking to prevent pregnancy and improve hormone-related problems like period pain or acne.

Once you’re already taking TriRegol, you can use DrEd’s online doctor service to reorder your triadene easy, with no appointments or face-to-face consultations. Click below to start your assessment.

3 month course £19
6 month course £24

Prices include delivery and prescription.

What is TriRegol?

TriRegol is a combined hormonal contraceptive pill (a CHC), which you can take if you are sexually active and don’t wish to become pregnant. It comes in tablet form, which you take orally (by swallowing). TriRegol is also known simply as “the Pill”.

It contains a combination of hormones, ethinyl estradiol and levonorgestrel, which are versions of two naturally-occurring hormones called oestrogen and progestogen.

TriRegol is a triphasic contraceptive pill. This means that your TriRegol pill strip will contain three different sets of pills, containing three different levels of hormones. These three different levels of hormones reflect the different levels of hormones that occur naturally throughout your usual menstrual cycle.

Together, the hormones in TriRegol will stop you from getting pregnant in three ways:

  • By stopping your ovaries from releasing their monthly egg (ovulation).

  • By thickening the fluid (mucus) of your cervix, so it’s difficult for sperm to pass through on its way to fertilise an egg.

  • By thinning the lining of your womb, so a fertilised egg is less likely to grow there.

TriRegol, or any Pill, will not stop you from getting a sexually transmitted infection (an STI), like chlamydia or gonorrhoea. Only condoms can do this.

Can TriRegol also treat acne?

Sometimes, GPs prescribe the Pill to people who have acne, or bad skin. Certain versions of the Pill can make the symptoms of acne better.

However, acne is also one of the most common side effects of taking TriRegol (affecting around 1 in 10 people). If you find your acne symptoms are a problem for you, speak to your nurse or GP for your options.

As well as the Pill, there are other treatments, made specifically to treat the symptoms of acne. These may work better for you, especially if you don’t want or need to be on a hormonal contraceptive.

Can you get TriRegol on the NHS?

You can get TriRegol on the NHS in the UK, with a prescription. You can only get a prescription from a licensed GP, which can be done either on the NHS or privately. Private services include private medical centres, and online doctors’ services, like Superdrug Online Doctor.

What side effects can TriRegol give you?

As with all medicines, it’s possible that you will get some side effects when taking TriRegol. If these side effects are ever severe, or unpleasant, you should seek immediate medical attention. Your GP may advise you to switch to another Pill.

Common side effects of TriRegol (affecting around 1 in 10) include:

  • Headaches.

  • Nausea or vomiting.

  • Stomach pains.

  • Mood swings (depression, anxiety).

  • Spotting (bleeding between periods).

  • Breast tenderness.

  • Increased body weight.

  • Changes to your skin (including acne).

Uncommon side effects of TriRegol (affecting around 1 in 100) include:

  • Migraines.

  • An increased risk of breast cancer.

  • High blood pressure.

  • Vomiting or diarrhoea.

  • A loss of, or an increased libido (interest in sex).

Rare side effects (affecting 1 in 1,000) can include:

  • Problems with contact lenses.

  • Skin disease.

  • Weight loss.

  • Hypersensitivity.

  • Crohn’s disease.

Some extremely rare and serious side effects (affecting up to 1 in 10,000 people) are:

  • Liver cancer.

  • Heart attack.

  • Blood clots (thrombosis).

  • Visual disturbances.

A full list of TriRegol’s side effects can be found on the leaflet in your pill packet. If you get any side effects that aren’t listed there, you should tell your GP. You can also report your side effects via the Yellow Card Scheme ( to help improve our knowledge of the safe use of TriRegol.

How can you switch to TriRegol from other contraceptives?

There are different instructions for starting TriRegol, depending on whether you are switching from another form of contraceptive, and depending on what kind of contraceptive this is.

Switching from another CHC (e.g. another combined pill, a transdermal patch, or a vaginal ring) - take your first TriRegol pill the day after the last active tablet of your previous pack of CHC pills, or the day after your transdermal patch or vaginal ring is removed. You must take this first TriRegol pill later than the day after you would usually have your usual pill-free/inactive pill/patch-free/ring-free break, or you will not be protected from pregnancy straight away.

Switching from a progestogen-only pill (a POP) - take your first TriRegol pill the next day after stopping taking your last POP. You will be at risk of pregnancy for the first 7 days of switching to TriRegol, so use condoms if you have sex.

Switching from the implant or a contraceptive injection - take your first TriRegol pill on the day that your implant is removed, or on the day when your next contraceptive injection would have been due (or a few days before the implant is removed/injection due) and you will be protected from pregnancy straight away. If your implant is expired (past its renewal date), or you have gone beyond when your injection was due, you will need to use condoms for the first 7 days of taking TriRegol if you have sex.

Not switching from a hormonal contraceptive to TriRegol - take your first pill on the first day of your period (when you start bleeding). You will be protected against pregnancy straight away. If you take your first pill on any other day of your cycle, you should use condoms for the first 7 days, when having sex.

Does TriRegol affect weight and mood?

Some people claim to experience weight or mood changes on the Pill. About 1 in 10 people on TriRegol will report an increase in weight and mood swings. However, the weight changes are usually due to water retention and should return to normal after stopping your Pill. There is also no strong evidence that the Pill causes mood swings.

If you’re worried about your weight, or your mood, speak to your nurse or GP. You may feel like TriRegol may not be right for you, but there are also things you can do to manage your weight and mood. You can also talk to your doctor for their advice.

What if I miss a dose of TriRegol?

You should take one TriRegol pill a day, at around the same time every day. It’s important with phasic pills to take your doses properly, because they contain different levels of hormones across the pill pack, to match your natural hormonal cycle.

If you are less than 12 hours late in taking your usual pill, don’t worry. Take your missed pill as soon as you remember, even if this means taking two in one day, and carry on tomorrow as usual. You will still be protected against pregnancy.

If you are more than 12 hours late in missing a pill, you may be at risk of pregnancy. Follow the instructions below, for what to do when you miss each type of TriRegol pill in your pack.

Missing a pill in the first week of your cycle - take your missed pill as soon as you remember, even if this means taking two in one day. Carry on tomorrow as usual, but use condoms if you have sex in the next 7 days.

Missing a pill in the second week of your cycle - take your missed pill as soon as you remember, even if this means taking two in one day. Continue tomorrow as usual, you will still be protected against pregnancy, as long as you took your pills correctly in the first week of your cycle.

Missing a pill in the third week of your cycle - take your missed pill as soon as you remember, even if this means taking two in one day. Carry on tomorrow as usual, but skip your usual tablet-free break between packs by starting your next pack on the day after the current one finishes. You may get spotting between periods.

If you’ve missed any tablets in your TriRegol pack, and you don’t get your usual withdrawal bleed, you could be pregnant. Take a test to make sure.

A good way to remember to take your daily TriRegol pill is to set an alarm on your phone, or to take your pill at a memorable time each day, like just after an evening meal.

Can I take TriRegol?

You can take TriRegol as long as it has been prescribed directly to you by a licensed GP or nurse. TriRegol is a prescription medication, so it will have to be approved first by a medical professional. Taking prescription medication without permission from a doctor is illegal and potentially very unsafe.

When you are getting your prescription for TriRegol, your doctor will ask you a few questions about your medical history. It will not be safe for everyone to take TriRegol.

You shouldn’t take TriRegol if:

  • You are pregnant or breastfeeding.

  • You have a history of breast, cervical or liver cancer.

  • You have a history of heart attacks.

  • You have a type of diabetes with complications.

  • You have high blood pressure.

  • You are allergic (hypersensitive) to any of TriRegol’s ingredients.

  • You have a history of or are at risk of getting a blood clot (like DVT or PE).

It is also not advised to take TriRegol if you are currently taking the following medicines:

  • Certain antibiotics (for example griseofulvin and rifampicin).

  • Certain medicines used in the treatment of HIV and Hepatitis.

  • The herbal remedy St. John’s wort.

  • Certain medicines used to treat epilepsy.

When taken alongside TriRegol, these medicines may stop it from working and could put you at risk of pregnancy and other health problems.

How does TriRegol compare to other pills?

There are a lot of pills out there. Below is a table of just some of the hormonal contraceptive pills that are currently available for use in the UK. Ask your GP for more detailed information if you’re not sure which pill is right for you.


CHC or PoP?

Monophasic or phasic?

Potential benefits

Potential drawbacks

TriRegol  CHC   Triphasic Phasic pills better mimic the changing hormone levels of your natural period Not suitable if you regularly miss or forget to take your Pill
Cerelle  PoP  Monophasic  You usually have fewer negative side effects with a PoP because they contain less hormones Not suitable if you regularly miss or forget to take your Pill
Rigevidon  CHC  Monophasic  CHC pills can help with heavy periods and are easy to take CHC pills can lead to more side effects than PoP pills
Gedarel  CHC  Monophasic  CHC pills can help with heavy periods and are easy to take CHC pills can lead to more side effects than PoP pills
Millinette  CHC  Monophasic  CHC pills can help with heavy periods and are easy to take CHC pills can lead to more side effects than PoP pills
  • CHC = combined hormonal contraceptive pill (containing a combination of the hormones oestrogen and progestogen).

  • PoP = progestogen-only contraceptive pill (containing the hormone progestogen only).

  • Monophasic = this is the most common type, where each pill in your packet will contain the same amount of hormones.

  • Phasic = this is where your pill packet contains two or three different types of pill, containing different amounts of hormones. These need to be taken in the right order. They can be biphasic (with two different amounts) or triphasic (with three different amounts).


Electronic Medicines Compendium (2014). TriRegol. Gedeon Richter.

Electronic Medicines Compendium (2016) Cerelle. Gedeon Richter.

Electronic Medicines Compendium (2016) Rigevidon. Gedeon Richter.

Electronic Medicines Compendium (2016). TriRegol coated tablets. Consilient Health Ltd. [Online] Available at: [Accessed 02 November 2017].

Electronic Medicines Compendium (2017) Gedarel. Gedeon Richter.

Electronic Medicines Compendium (2017) Millinette. Gedeon Richter.

If you have a question about this service, please email with the question, and one of our doctors will get back to you within 24 hours.

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